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Continuing Evolution of Life Sciences Facilities

November 15, 2022
Jose Jimenez
It’s no secret that the Life Sciences industry is experiencing record levels of funding. Improvements in the development of advanced therapeutic medicinal products, and new CAR T-cell therapy approvals are contributing factors driving increased funding. In fact, drug approvals have increased by 250% over the last three years – demonstrating exceptional successes and advances in biopharmaceuticals and therapeutics – and driving continued high levels of funding. The unprecedented funding comes from government and public sources, as well as venture capital. According to Cushman & Wakefield’s Life Sciences Update (2022 October), total U.S. National Institute of Health (NIH) funding grew by 3.1% YoY in 2021 … Growth in funding over the past five years has averaged +7.6% per year, which is faster than the 26-year average (+5.5%).

Combined with the “constant discovery” nature of the life science industry, increased funding has been fueling a burst in life sciences construction across the globe.  There is also increased attention on reshoring to overcome global supply chain challenges. Working with clients across the life sciences market, we’ve observed some key market trends that are enhancing the focus on speed to market and flexibility for future expansion, as well as broader social trends related to sustainability and diversity.

  1. Focus on process intensification and digitalization

New products and technological improvements are evolving the biopharmaceutical industry research and manufacturing processes. One of the most significant impacts recently is the dramatic rise of cell and gene therapies, which is fueling the need for low-volume manufacturing facilities. From a capacity planning perspective, this places greater focus on maximizing productivity in smaller footprints. The adoption of single-use technologies (SUT) and continuous manufacturing are also enabling productivity increases and a means to reduce the risk of contamination. Some examples of SUT with increased popularity are media bags, TFF devices, bioprocess containers, filter cartridges, and disposable chromatography devices. Additionally, there is interest in applying AI tools to drug research and development giving rise to the use of AI applications for small-molecule discoveries.

  1. Greater adoption of modular and prefabricated systems

Speed to market expectations, coupled with limited workforce, have also increased the need for greater adoption of modular solutions and off-site prefabricated skid assemblies for building utilities and process systems. Not new to the industry but currently in high demand are the prefabricated, panelized clean rooms. We’ve also observed a higher demand for modular clean room PODs. Process super skids have also been adopted successfully and are more commonly in use (e.g., bioreactor/fermentation systems, media and buffer prep vessels, and WFI or RODI distribution systems, among others).

  1. Commitment to environmental sustainability

Research labs and production facilities require complex and robust infrastructure that are heavy consumers of energy. They can also generate significant levels of waste. Improving sustainability is a key goal for many life sciences companies, therefore, many have committed to pursue significant environmental targets. Of course, this trend isn’t specific to the life sciences market – Gilbane recently released our ESG strategy report, Blueprint for Impact , which outlines our commitment to affecting positive environmental change and raising environmental awareness, and supporting our clients’ sustainability goals. We also seek out and work with suppliers who are also committed to reducing their carbon footprint through conservation of resources, practicing waste minimization techniques, and maximizing local sourcing.

  1. Diversity & Economic Inclusion

The business case for diversity and economic inclusion (DEI) is especially strong in the life sciences industry. As with other industries, life sciences clients who are actively driving diversity and inclusion can foster innovation, attract and retain the best talent, and increase profitability. Construction projects can offer an opportunity to support life sciences companies’ goals related to DEI by engaging a broad array of diverse suppliers and vendors. For example, Gilbane’s commitment to supplier diversity is long-standing and based on long-term capacity building, investing in our diverse business partners through Gilbane’s Rising Contractor training program. Gilbane also seeks to leverage its projects for economic inclusion and announced a $4 billion commitment in awards to diverse and disadvantaged businesses over the next five years (2022-2026).




About Authors
Jose Jimenez is vice president and life sciences center of excellence leader.  In this role, Jose supports Gilbane’s life sciences clients and project teams with speed to patient goals, and a focus on safely delivering quality facilities. His 24 years in the construction industry include directing major capital programs involving new building construction, building additions, and renovations of active cGMP manufacturing and research facilities ranging between $5 million and over $500 million per project. A trusted leader in the life sciences market, Jose has spoken on topics such as “Building Cleanrooms at Warp Speed” for the American Pharmaceutical Review and “Rapid Cleanroom Builds for COVID-19 Facilities: Lessons Learned” for Pharma’s Almanac. Jose is a member of both the International Society of Pharmaceutical Engineering (ISPE) and the Construction Management Association of America (CMAA). 
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